A review of 643 unique journal articles related to estrogen and migraine establishes that the two are indeed linked. My initial reaction to this was “duh,” but stating the fact so plainly helps legitimize further clinical research on the topic.
The article concludes:
Epidemiological, pathophysiological, and clinical evidence link estrogen to migraine headaches. Triptans appear to provide acute relief and also may be useful for headache prevention. Clear, focused, and evidence-based treatment algorithms are needed to support primary care physicians, neurologists, and gynecologists in the treatment of this common condition.
In possibly related news, a study published in an oral surgery journal states that “the affective component of pain my be enhanced during the low-estrogen phase of the menstrual cycle in healthy women.” That is, women are more sensitive to pain from oral surgery when their estrogen is low. Perhaps the link isn’t only migraine-specific, but pain in general.
There’s tons of information available if you want to learn more about estrogen or menstruation and migraine. I recommend ACHE’s women and migraine section and their related newsletter articles (look under headache sufferer subgroups, then under women), and the National Women’s Health Information Center’s migraine section.