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Trexima Study Presented at AAN Meeting

Just when I was ready to concede that Trexima might provide a migraine treatment better than existing meds, I read the fine print.

The articles say that 57-65% of participants who took Trexima, which combines Imitrex with naproxen (a NSAID, a relative to Advil), reported pain relief after two hours. In comparison, 50-55% of participants who took Imitrex and 28-29% who took a placebo reported relief after two hours. After four hours the percentages rose to 72-78% for Trexima, 61-66% for Imitrex and 37% for the placebo.

The treatment that most accurately compares to Trexima is Imitrex taken simultaneously with naproxen. Why wasn’t this combination studied? My guess is that including this comparison wouldn’t show enough of a difference between the two treatments to justify the FDA approving Trexima as a new drug. Thus, not allowing GSK to continue holding the Imitrex patent.

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FDA to Review “New” Migraine Drug

The FDA has accepted for review a “new” migraine drug, Trexima, that was developed by Pozen for sale by GlaxoSmithKline. Trexima is a combination of sumitriptan (Imitrex) and naproxen sodium (the ingredient in Aleve).

Hmm, could this be GSK’s desperate attempt to hold the patent (set to expire in 2009) on a drug that brings in loads of money? Patients who spend small fortunes on triptans each year would probably be willing to forego the convenience of taking one pill instead of two.

You gotta love CNN’s headline: Glaxo’s New Drug May Save Migraine Sales. Who knew that you could buy and sell migraine. I’d be happy to put mine up for sale. Think anyone would buy it on eBay?