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Generic Imitrex (Sumatriptan) Tablets & Injections Available in US
By Kerrie | January 30, 2009
Tablet and injection versions of generic Imitrex (sumatriptan) are available in the US. Doses are 25mg, 50 mg, and 100mg tablets and 4mg and 6mg injections (kits or pre-filled syringes). Patients have reported prices between $35 and $200! Imitrex’s patent doesn’t actually expire until February; a reader suggested it might be less expensive then.
The generic hasn’t been as effective as the brand name drug for some patients. In Generic Imitrex (Sumatriptan) — Is it as Effective as Brand Name Imitrex, blogger Doc Shazam writes:
…I have taken 2 of “Dr. Reddy’s” generic sumatriptan tablets with almost no relief of headache symptoms, but a plethora of side effects, including aching muscles, nausea, “light headed” feeling and general dis-ease.
Read about other patients’ experiences in their comments on earlier posts on The Daily Headache:
- 11/18/08: Generic Injectable Imitrex (Sumatriptan) Now Available
- 2/4/08: Generic Form of Migraine Abortive Imitrex Available By December 2008
January 30th, 2009 at 1:21 pm
I’ve been using the generic injections for a few weeks now, and they seem to work as well as the name brand for me.
January 31st, 2009 at 7:29 pm
I have use the generic 25 mg for two months and I’m very disappointed. It most definitely is not as effective as Imitrex for me. I know in theory it should be the same formula but it hardly works at all. I had to take twice as many with half the results. I checked online and fnd that other people felt the same way. Anyone have any guesses as to why?
February 1st, 2009 at 12:22 pm
Generic tablets are actually more expensive at the moment
February 2nd, 2009 at 8:43 pm
Same as Diana. I had reported that a 2 injection kit is costing me about $65 for the generic as opposed to $73 for the brand.
Has anyone ever heard of injectable in a regular syringe? I detest the auto-injector. An email to GSK was fruitless on that topic.
February 7th, 2009 at 8:57 pm
I’m not sure if there’s a generic 2.5ml vial, but there used to be one that GSK marketed. Presumably, the target market was hospitals.
Personally, I pull out the little syringes from the cartridge such that I can use only half its contents. It’s not always as effective, but it greatly reduces side effects and, of course, cost.
I’ve also noticed that if I take the time to warm up the syringe up to body temperature, there’s no pain during injection, whereas, otherwise, it’s a coin toss.
I, too, would prefer to buy syring/needle and drug separately, even for a modest or nonexistent discount.
February 9th, 2009 at 2:47 pm
I haven’t tried the generic injection yet, but have used the generic tablets and they seem as effective as the regular tablets for me. I did get the achy chest, etc, but I often get that with the name brand as well. Not every time. In fact, my reactions to the same medication from one time to another vary so much that I almost think I’d have to wait until I had finished several packages of the generic to compare.
February 26th, 2009 at 3:11 pm
I have tried the generic sumatriptan for 2 migraines and it didn’t work well for either using 50mg My dr suggested doubling up to 100, which I tried today. It made the headache ease off, but not go away completely and the tightness in the chest and throat sure seemed worse! I think I will ask for “no substitution” scrip. It’s not worth it to take twice as much with half as much relief! I also submitted a complaint on the FDA website.
March 8th, 2009 at 10:42 am
I just found out I have ulcers and despite my family doc and g.i. doc’s silence on this issue I am guessing that these are as a result of years of Imitrex. Anyone else in this boat? Suggestions?
March 30th, 2009 at 1:26 pm
I have been using generic sumatriptan since 1999, primarily from Indian sources — I use the 100 mg. tablets (they work fine for me), I currently use a generic form of 100 mg. sumatriptan capsules (work really great because they digest faster) and I’ve also tried the ampules they used to sell (can’t seem to find them any longer) that you snap off, then use a diabetic syringe for the injection. The very slim needles that diabetics use are really painless, as opposed to those ghastly injection pens (difficult to use too) from GSK.
I also pull out the little syringe from the refill kit from GSK and use a bobby pin to do the injection, but the needle they use is unnecessarily a heavier gauge than a diabetic needle, which is one reason the GSK injection pen is so uncomfortable. Also, if you check the FDA web site for standards of generics vs. the equivalent name brand, the generics must be within a tolerance of 80% to 125% of equivalent patent drug’s dosage efficacy. That’s a possible spread of 45%. I can’t find the specific guidelines from the FDA site right now, but here’s the quote from an FDA letter sent to the National Association of Boards of Pharmacy:
Quote:
This approach allows the possibility of scaling the bioequivalence ‘goalposts’ (e.g., the boundary of 80 - 125%) based on variability of the reference listed (innovator) drug.
End quote.
http://www.fda.gov/cder/news/ntiletter.htm
If I had more time I’d look for the FDA guidelines for generics, but this will come as a shock to many people. Generics are not necessarily bioequivalent to their name brands! I use generics but some people may not respond as well. No wonder some people don’t feel the same effects with generics — in spite of what doctors and popular advertising tell you, they are not necessarily exactly the same because of the variant efficacy that’s tolerated by the FDA.
And one final note, the gold standard for treating migraines is still 100 mg. of sumatriptan, not 25 mg., not 50 mg. That’s the dosage that is used as a comparison for the other triptan trials. So keep that in mind. I’ve had migraines since I was 8 years old, so I’m an expert, unfortunately. Hope this helps someone out there!
June 3rd, 2009 at 6:53 am
I wondered if anyone knows if the generic sumatriptan injections will fit in the Imitrex pens? It seems like there is a shortage of sumatriptan kits from the manufacturer. I have a couple of Imitrex pens and my insurance will only pay for the generic medication, but it’s all useless without a pen. Please help and email me at matthew.peterson@mchsi.com
June 23rd, 2009 at 10:21 pm
Generic for Imitrex needles are jagged. The needles in the original Imitrex were painful, but the generic are horrible. Feels like a square needle. I contacted my doc and FDC to register the complaint. I’m experiencing more sever brusing and bleeding from the injections. Anyone else going through this, please contact their docs and register complaints with the FDC.
July 2nd, 2009 at 3:35 am
I spent two days using the generic sumatriptan injections - did not take my headache away. I found one last real imtrex in the closet and it took the headache away immediately. The above comment on the ‘possibiltiy of scaling the bioequivalence…” makes sense, the generic seemed weaker and less effective. Also makes sense for their corporate profits. Once again, profit trump healthcare.
July 8th, 2009 at 1:24 pm
I have been taken Imitrex for 3 years and have been very pleased with the results. My pharmacist gave me the generic this time and I have used it twice this month….My regular dose was not enough. I ended up taken twice as much just to get the headache to go away and then it came back much harder. I have had this happen two times, now. The generic just doesn’t work for me. I don’t know why because I thought that it was supposed to be the same as Imitrex. I just spent one of the worse nights of my life. I am going back to the Imitrex.
July 12th, 2009 at 8:02 am
I have trouble getting Imitrex prescriptions filled. Mostly I’m charged double because there are two prefilled injections per box. Some people might not know to question this.
Walmart’s mail order service fills three months supply at once but they keep sending 12 boxes with 12 injection pens, ignoring my notes pens.
I got a prescription yesterday. I had stapled a note on the insurance form and also on the prescription. Ok, they read the note this time, but this is what they sent … three boxes, each had five little jar things of Imitrex liquid. I don’t have any syringes to use with thse and need to call my doctor or a pharmacy. This prescription cost $1,484, I pay 1/4 and my insurance pays the rest. Yikes, I am about ready for Medicare and I don’t think they cover these jections.
When I get the prefilled injections, I use a screwer stick as a plunger. I have no bleeding, bruising, or pain this way.
Generic doesn’t seem to work as well.
July 12th, 2009 at 8:05 am
I didn’t notice any difference between the needles of generic and Imitrex. I can’t imagine that generic is purposly made below standards because they wouldn’t get repeat customers. I do wonder why the heck this stuff is so expensive.
July 14th, 2009 at 5:45 pm
I’m experiencing my first cluster headaches since 2005. I was hoping that moving from NYC to the desert was the cause, as I had been having severe bouts, several times per year previously, the longest bout actually lasting over two months.
I started using ’stale-dated’ Imitrex injections that I had left over, some having expired in ‘02, the rest in ‘06. So far the results have been fine, no issues, perhaps less side effects.
Today I received 5 single dose vials of the generic; the inept pharmacist didn’t even know that I would need syringes to administer it. I had to go online (to YouTube) to learn how do draw from the vial and how to give a subcutaneous injection. I’ve not tried it yet, and am not thrilled at the prospect of having to use a real needle (yeah I’m a wimp), I never really liked the Imitrex auto injector pen either for that matter.
Anyway, I’ll report back here in a few days once I’ve tried the generic and let y’all know how it works for me…
-Paul D
July 14th, 2009 at 5:48 pm
Just to clarify the above: I was hoping that my four year hiatus from regular clusters was caused by my move to the desert.
-PD
July 15th, 2009 at 6:57 am
I have had migraines for about 20 years and when I discovered Imitrex I thought it was a miracle drug. It still works for me. Have tried the generic and do not get the same results. I took one tablet, no relief, took a second one within the hour (a no no) and promptly threw up. Four hours later I took a real Imitrex & it ended the headache within an hour.
July 18th, 2009 at 1:34 pm
Four more days along in a cluster that is going on two weeks. My insurance has only so far covered 5 doses of generic sumatriptan. It appears to work as well as my imitrex injector kits that expired in ‘06.
Most disturbing is that the headaches seem to be coming fast and furious now, approx every 6-8 hours. I find myself having to ignore the 2x/day max and use when necessary.
I’ve also been informed by my PCP that my insurance will require an Rx from a neurologist if I am to receive enough generic to last a month @ 2x/d. I’m just lucky that I still have some of the old imitrex left over for now.
Still throbbin,
-Paul D
July 29th, 2009 at 6:10 am
I have been getting migranes is back in the day when they gave your caffergot, which did not work, but suffice it to say, a long time. I was given Imitrex about two years ago and it worked. I could not beleive that something besides a shot in the emergency room got rid of these horrible headaches. Recently, I like many was given the Sumatriptan (without any say in the matter) and it was just like the old days for me. I spent two days with a horrible headache, throwing up and so on, you know the routine. It took me another entrie day to get my pharmacy and my doctor to work together to get a Imitrex percription.
I might save a few dollars on the generic, but when I am in the middle of a migrane, I could care less about $10 or so dollars. I want something that is going to get rid of the headache. What happened to the good old days when you doctor wrote you out a percription and the pharmacy filled it out…the way the doctor wrote it and not the way the pharmacy would finacially benefit the most. I was told that the only way to get the percription that your doctor orded was to make the doctor note that it must dispensed as percribed on the ‘cript’.
Good luck to all who suffer,
Robin R. in Minnesota
August 19th, 2009 at 11:36 pm
I wonder how many of these posts are fake by Imitrex employees to scare people away from the Generics. I haven’t tried the generic yet myself, but I find it hard to believe they don’t work at all like so many are claiming.
August 26th, 2009 at 1:24 pm
I decided to try the generic sumatriptan and have found it to be less effective as the Imitrex. Headaches return sooner and with more intensity. I’ve noticed a significant increase in dizziness which actually did not exist with Imitrex. While the cost is higher I’m going back to name brand. As for the Imitrex injections, ouch! I don’t even use the kit, I pull the syringes out and administer the does myself.
September 10th, 2009 at 11:38 am
I’m just curious, where do any of you live that are paying less than $100 for the injection refill. I live on Long Island, and just found out that the price went up again, and is now $185 per box. I’ve checked, that’s the cheapest!
October 5th, 2009 at 1:35 pm
At first I was thrilled to see Imitrex finally available as a generic in hopes that I could drop my expensive monthly pharmacy plan to a generic only plan that would save me alot of money, but now I am beginning to wonder. Since switching to the generic products, pills, nasal sprays and injections, none of them are working for me nearly as well as the original Imitrex products. I am especially disappointed by the injections which use to knock out my migraine headaches within minutes. Now, the generic formula can help a little or not a all. Within the last month I have had one of the worst series of headaches I have had in years because the generic products gave me little or no relief. I am afraid I am going to have to keep my expensive drug coverage and go back to the original formula.
December 4th, 2009 at 12:36 pm
My prescription service recently went from supplying me with Imitrex to the generic. I have tried the generic on a number of occasions and it is not as effective and does not get rid of the migraine the way Imitrex does - not even close.
December 21st, 2009 at 2:29 pm
In the last few months, I have used the generic sumitriptan succinate in pill form from two different manufactuers, Dr. Reddy and Teva. The generic from Dr. Reddy was reasonally effective in relieving my migraines but the generic from Teva was barely effective at twice the 50 mg dose. Quality control must be really bad at the generic manufacturers. I have suffered migraine headaches for 60 years.
December 27th, 2009 at 4:24 pm
I have had migraine headaches for a little over a year now. For the first few months I suffered through with over the counter meds that didn’t work … and I really suffered. I was finally able to get in with a doctor who recognized that I was having cluster migraines that went on for 3 to 4 days. My doctor prescribed Imitrex and it was like a wonderful gift. I only had to take a half of 50mil tablet and it would stop the pain in about 15 minutes. My insurance only covered half of the $225.00 cost, but it was worth it for me to pay my share. When the generic hit the market, my insurance would no longer pay for the Imitrex and would only allow a benefit for the generic brand. And to make matters worse, my pharmacy quit carrying the Imitrex and only carried the generic. So I didn’t have a choice and had to buy the generic when I filled my last prescription. I had my first chance to try the generic on Christmas Eve 2009 … and I am sorry to say it was a nightmare. My headache was very severe … more painful than usual so I decided to take a whole table (50 Mil). I waited for an hour but got absolutely no relief. So I then took another table (50 mil) … and waited again for an extremely painful hour and still no relief. I became very weak and unable to walk by myself. I fell into a door and would have ended up in my bedroom floor if it had not been for my husband. In fact I would have probably ended up spending the night in my own vomit on my bedroom floor if I hadn’t had help. In my opinion, the generic is ineffective and the side effects (muscle weakness and dizziness) can prove dangerous for anyone who might be living alone.
I saw someone’s comment on this board that suggested that the people here who didn’t have good things to say about the generic were only people who were “fake” and were Imitrex employees. That’s about the most ridiculous thing I’ve ever heard. I intend to contact the FDA and express my concerns and tell them about my experience.
December 30th, 2009 at 9:45 am
I was using brand Imitrex for about 6 years and it worked pretty well. I started using the generic Imitrex caplets (100mg) a few months ago. I’ve found that, for me, they are totally unacceptable. Each time I’ve tried to use it for a breakthrough, I’ve maxed out and ended up vomiting all day. Luckily, I had a few brand-name at work, so I could rid myself of the migraine the next day. My insurance company has shifted the cost to the high-cost category for the brand name Imitrex, so I’ll have to switch to something else.
December 30th, 2009 at 2:53 pm
Imitrex always worked very well for me - the Dr. Reddy generic is OK, but now I have the Teva, which is significantly worse. I’ve upped my dosage to 100mg, and sometimes still need two doses. My neurologist told me that it is well known that the generics don’t work very well.
January 1st, 2010 at 10:37 pm
If you use Imitrex injections you don’t have to use the pens or kits. It is available in 0.5 ml single dose vials from GSK. They come 5 per box. The recommended dosage is 0.5 ml however, when using an insulin syringe you can control how much you take. I’ve had chronic cluster headaches for 19 years and use it quite often. With trial and error I have learned that 0.2 ml will give me complete relief as quickly as the entire 0.5 ml dose. The benefit is that I can get 3 1/2 doses from each vial thus saving tons of money and of course experiencing less side effects. I have no idea if the vials are available in a generic version but you will save so much money that it really doesn’t matter. If anyone has any questions about it feel free to email me at grizzlymail@cox.net. Good luck and God bless.
January 14th, 2010 at 9:46 am
I’ve suffered extreme migraines my entire life, now 20 years old. My insurance company (BluCross Federal), yes FEDERAL insurance refuses to pay for imitrex. The only way I could get it was to hit catastrophic limit for the year and get script after script so I would have a decent supply, my insurance company had no choice but to pay the $1000 some odd dollars for 20 pills. Needless to say, I’ve been waiting years for GSK’s patent to run out. Now that the generics are here, after hearing what everyone is saying about the generics I’m quite hesitant to. The whole thing sounds like a sham by GSK to get Imitrex back on the market. Let me tell you all something, pharmaceutical companies run America and can do whatever they want, they’re in bed with the FDA so good luck getting a response from them. For relief, I’d suggest morphine w/ ibuprofen. Myself I take 150mg morphine sulfate and about 1600mg ibu by mouth for migraines.
January 28th, 2010 at 12:16 pm
I was one of the first to ever use Initrix by injection. I have suffered from migraines since i was 14. I am now 65. In 1995 I believe it was. I was in a hospital with a migraine in Connecticut. A nuerologist visited me and he had imitrix put into my vein in the hand through a tube. It was a miracle. He told me to come by his office the next day and his nurse would teach me how to give the shot to myself. At that time you had to build this whole little space ship type of injector…. a couple of years before the auto injector. Skip forward to 1999. I was living in Florida, and my doctor there just happened to be a migraine sufferer, too…and male, very unusual. He gave me a lot of samples of sumatiptans, and I found Zomig worked as good as the shot ever did. It took longer, sometimes up to an hour, but in the long run just as effective. And of course, cheaper….skip forward to 2010, my insurance company will now only pay for 4 5mg tabs (equivalent to 100mg sumatriptan)a month… so far, I have tried the sumatiptam twice, and it has worked OK…As I normally use 12-16 a month, I will have to pay for the rest of them, and…the generic imitrix is so so so much cheaper than let say CVS.