Harvard Medical School researchers have found brain changes in patients with migraine. For a more accessible article about the study, read The Migrainous Brain: What You See Is Not All You Get? by Peter Goadsby of the Institute of Neurology. I fear this more than living the rest of my life in pain. It doesn’t necessarily mean changes in brain function, but the possibility is unsettling.
Using two forms of magnetic resonance imaging the researchers studied 24 patients with migraine (12 who had migraine with aura and 12 without aura) and 15 age-matched healthy controls.
There were no differences in cortical thickness in motion-related areas between the participants with migraine who had aura (neurological disturbances such as illusions of flashing lights, zig-zag lines, or blind spots) and those who did not, but the area of cortical thickening in one area corresponded to the source of cortical spreading depression previously identified in a person who had migraine with aura.
As well as showing that there are some structural differences in the brains of people with migraine, the position of the changes could help to explain why some people with migraine have problems with visual processing even in between attacks.
In 2004, Teri Robert of About.com‘s Headache and Migraine section wrote about a study examining the risk of brain lesions in people with migraine. It’s different than the current study, but scary nonetheless.
In case you’re not scared enough: Taking Topamax on a long-term basis increases your risk of developing kidney stones, according to a recent study.
Researchers found that taking topiramate on a long-term basis, or for about one year, caused systemic metabolic acidosis — a buildup of excessive acid in the blood — as a result of the inability of the kidney to excrete acid. Topiramate use also increased the urine pH and lowered urine citrate, an important inhibitor of kidney-stone formation.
“These changes increase the propensity to form calcium phosphate stones,” Dr. Sakhaee said.
In the short-term study, urinary calcium and oxalate — a chemical compound that binds strongly with calcium and is found in most calcium stones — did not significantly change in people taking topiramate.
Kidney stones are solid deposits that form in the kidneys from substances excreted in the urine. When waste materials in urine do not dissolve completely, microscopic particles begin to form and, over time, grow into kidney stones.
Some sort of good news: Sumatriptan, the generic for Imitrex has been approved in Sweden. It will be available as soon as the European patent expires in 2007. Few of you actually live in Sweden, but it could indicate the likelihood of other European countries to follow their lead.
The graphic is from the motor cortex page of PBS‘s Probe the Brain section.
3 thoughts on “Headache & Migraine News”
Actually, migraine isn’t the only kind of chronic pain that alters the brain. Believe it or not, one year of back pain “shrinks” your brain about the same as 20 years of life with no pain. Was it 1cm2/year?
RE: Topamax–Hydrate, hydrate, hydrate.
As for brain changes…yeeeesh. (I have not yet had my MRI. Can you spell d-e-n-i-a-l?)
Thanks for making me laugh! And for the good advice on Topamax.
Interesting, scary, and yet, not surprising
But I’ve always hoped that if I ignored the possibility it would go away. 😉